Transcriptomic Alterations Induced By Vemurafenib after Treatment of Melanoma: A Comprehensive Bioinformatics Analysis

Melanoma is a highly aggressive kind of cancer with very poor prognosis. v-Raf murine sarcoma viral oncogene homolog B1 inhibitor vemurafenib has indeed harvested substantial clinical benefits. Nevertheless, its drug resistance also hampered scientists’ efforts towards successful melanoma treatment. In this study, we used data derived from the gene expression omnibus database to analyze effect on sensitive cell lines after Gene datasets GSE42872 (cohort 1), GSE127988 2), GSE110054 3) were included in analysis. We found 25 common differentially expressed genes 3 datasets, including 10 upregulated and 15 downregulated application. Analysis using web tool Timer showed significant correlation immune infiltration level skin melanoma. ontology enrichment analysis that treatment, all downregulation deoxyribonucleic acid replication cycle arrest. Meanwhile, related neurogeneration, extracellular matrix cell-cell adhesion significantly enriched three datasets. Kyoto Encyclopedia Genes Genomes pathways like P53, phosphatidylinositol 3-kinase-protein kinase B Ras-associated protein signaling administration. The findings candidate may not only reveal cellular sensitivity treatment but give rise better understanding mechanism arrest targeted therapy.